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Currently, the major effort in my lab is to characterize the role of a family of transcription factors know as zinc finger X-linked duplicated ZXD in immune system function.

Sumoylation of the zinc finger protein ZXDC enhances the function joe fontes its transcriptional activation domain. Gap junctional coupling in neuronal survival and death. We are currently pursuing the mechanistic differences and gene targets of the two ZXDC isoforms and further refining the models by which they alter transcription.

Mol Cell Biochem. Our current model for the activity of ZXDC invokes two different mechanisms. More recently, we have established that ZXDC participates in regulating genes important for the development and activity of myeloid cells, particular joe fontes of the monocyte lineage.

He was of Catholic faith. Last modified: Sep 13, Contact. Another aspect of my laboratory's work is a robust collaboration with Dr.

He was also a member of the Disabled American Veterans, and the local Commander club. University of Kansas Medical Center jfontes kumc. Neuronal gap junctions escort asuncion a role in the secondary neuronal death following joe fontes cortical impact.

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J Mol Biol. Neurosci Lett. You can still show your support by planting a tree in memory of Joseph Fontes.

Secondly, one isoform of ZXDC interacts with chromatin modifying enzyme complexes, leading to changes in enhancer activity that regulates genes necessary for monocyte differentiation and function. Contributions in memory of Mr.

Fontes was the owner and operator of Fontes Refrigeration in Massachusetts. Neuronal gap junctions: making and breaking connections during development and injury.

Fontes was predeceased by his wife, Mary Santos Fontes on December 15, Jambunathan S, Fontes JD. J Neurosci.

Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses. Services are private and will be held at the convenience of the family.

Knockdown of ZXDC by lentiviral transduction of human U cells le to impairment of differentiation and associated gene expression. First, ZXDC binds to and inhibits the activity of a transcriptional joe fontes B-cell lymphoma 6 protein Bcl6leading to increased transcription of specific genes, including the Chemokine C-C motif ligand 2 CCL2; also known as monocyte chemoattractant protein -1, MCP1.

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Andrei Belousov in the Joe fontes of Molecular and Integrative Physiology at KUMC, focused on the regulation and activity of the gap-junction protein connexin Cx36 in neuronal development and death following injury. He was also predeceased by his sister, Alice Camara. Trends Neurosci.

Biol Chem. Mol Immunol.